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KMID : 0939920070390030109
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대한암학회지
2007 Volume.39 No. 3 p.109 ~ p.115
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Glucose Transporter-1 Expression in Squamous Cell Carcinoma of the Tongue
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Choi Yoon-Seok
Kim Seok-Jin
Kim Jun-Suk
Choi Jung-Woo
Shin Bong-Kyung
Jung Kwang-Yoon
Baek Seung-Kuk
Kim Yeul-Hong
Kim Dae-Sik
Park Seh-Jong
Park Yong
Shin Hye-Jin
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Abstract
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Purpose: Tumor cells are known to express hypoxia-related proteins such as glucose transporter-1 (Glut-1). These hypoxia-induced changes may allow tumor cells to survive under sustained hypoxic microenvironments, and the surviving tumor cell under hypoxia may develop a more aggressive phenotype and so result in a poor prognosis.
Materials and Methods: The Glut-1 expression was analyzed by immunohistochemistry, and its association with the prognosis was assessed in 60 patients with squamous cell carcinoma of the tongue.
Results: The Glut-1 expression was diffuse with a membranous pattern, and the median percentage of Glut-1 positive tumor cells was 60% (range: 0.0∼90.0%). A high Glut-1 expression (the percentage of positive tumor cells ≥ the median value, 60%) was associated with the location of primary lesion, lymph node metastasis status and disease stage (p＜0.05). The expression of Glut-1 was correlated with the Ki-67 expression (r=0.406, p=0.001). Microvessel density, as represented by CD31 staining, was also correlated with the Glut-1 expression although its significance is weak (r=0.267, p=0.039). On the univariate analysis, the group with a high Glut-1 expression showed poorer overall survival than the group with a low Glut-1 expression (p＜0.05). However, the Glut-1 expression failed to show any independent prognostic significance on the multivariate analysis.
Conclusion: The expression of Glut-1 may be useful for predicting the prognosis and determining the treatment strategy for the management of squamous cell carcinoma of the tongue. (Cancer Res Treat. 2007;39:109-115)
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KEYWORD
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Tumor hypoxia, Glucose transporter-1, Squamous cell carcinoma, Tongue
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